KLF1 CLIA Kit for Human(Homo sapiens) | EIAab.comKLF1 CLIA Kit for Human(Homo sapiens)

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KLF1 (Gene name),

Krueppel-like factor 1 (Protein name ), KLF1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

KLF1(EKLF);

Protein name:

Krueppel-like factor 1;

Alternative:

Erythroid krueppel-like transcription factor(EKLF);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with CBP and EP300; the interactions enhance the transactivation activity. Interacts with PCAF; the interaction does not acetylate EKLF and inhibits its transactivation activity.

Function:

Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.

Subcellular Location:

Nucleus Colocalizes with SUMO1 in nuclear speckles.

Protein Attributes:

Sequence length:

362

Sequence:

50:

100:

150:

200:

250:

300:

350:

362:

SDHLALHMKR | HL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

111150

SMR:

Q13351

KEGG:

hsa:10661

String:

Q13351

UniGene:

Hs.37860

Pfam:

PF00096

STRING:

9606.ENSP00000264834

Uniprot:

Q13351

FOR

ELISA Kit for Human Krueppel-like factor 1

Cat.:

E10199h

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96T

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ELISA Kit for Human Krueppel-like factor 1

Cat.:

E10199m

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Packing:

96T

CLIA Kit for Human Krueppel-like factor 1

Cat.:

U10199h

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96T

CLIA Kit for Human Krueppel-like factor 1

Cat.:

U10199m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Krueppel-like factor 1

Cat.:

P10199Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Krueppel-like factor 1

Cat.:

P10199Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Krueppel-like factor 1

Protein for Human Krueppel-like factor 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Isolation, genomic structure, and expression of human erythroid Kruppel-like factor (EKLF)."
Bieker J.J.
DNA Cell Biol.15:347-352(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];TISSUE SPECIFICITY
2.

"The human erythroid-specific transcription factor EKLF localizes to chromosome 19p13.12-p13.13."
van Ree J.H. , Roskrow M.A. , Becher A.M. , McNall R. , Valentine V.A. , Jane S.M. , Cunningham J.M.
Genomics39:393-395(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
3.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT PRO-102
tissue: Lung.
5.

"Acetylation and modulation of erythroid Krueppel-like factor (EKLF) activity by interaction with histone acetyltransferases."
Zhang W. , Bieker J.J.
Proc. Natl. Acad. Sci. U.S.A.95:9855-9860(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION;INTERACTION WITH CBP; EP300 AND PCAF
6.

"A dominant mutation in the gene encoding the erythroid transcription factor KLF1 causes a congenital dyserythropoietic anemia."
Arnaud L. , Saison C. , Helias V. , Lucien N. , Steschenko D. , Giarratana M.C. , Prehu C. , Foliguet B. , Montout L. , de Brevern A.G. , Francina A. , Ripoche P. , Fenneteau O. , Da Costa L. , Peyrard T. , Coghlan G. , Illum N. , Birgens H. , more...
Am. J. Hum. Genet.87:721-727(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ROLE IN ERYTHROPOIESIS;FUNCTION AS TRANSCRIPTIONAL ACTIVATOR OF CD44 AND AQP1;SUBCELLULAR LOCATION;VARIANT PRO-102;VARIANT CDAN4 LYS-325;CHARACTERIZATION OF VARIANT CDAN4 LYS-325
7.

"Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin."
Borg J. , Papadopoulos P. , Georgitsi M. , Gutierrez L. , Grech G. , Fanis P. , Phylactides M. , Verkerk A.J. , van der Spek P.J. , Scerri C.A. , Cassar W. , Galdies R. , van Ijcken W. , Ozgur Z. , Gillemans N. , Hou J. , Bugeja M. , Grosveld F.G. , more...
Nat. Genet.42:801-805(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS REGULATOR OF FETAL-TO-ADULT GLOBIN SWITCHING;INVOLVEMENT IN HBFQTL6
8.

"Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF)."
Mas C. , Lussier-Price M. , Soni S. , Morse T. , Arseneault G. , Di Lello P. , Lafrance-Vanasse J. , Bieker J.J. , Omichinski J.G.
Proc. Natl. Acad. Sci. U.S.A.108:10484-10489(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 51-90 IN COMPLEX WITH YEAST TFB1;FUNCTION;INTERACTION WITH TFB1; CREBBP AND EP300
9.

"Mutations in EKLF/KLF1 form the molecular basis of the rare blood group In(Lu) phenotype."
Singleton B.K. , Burton N.M. , Green C. , Brady R.L. , Anstee D.J.
Blood112:2081-2088(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS BLOOD GROUP-IN(LU) TYR-299; LEU-328; HIS-328 AND GLY-331

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